(S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile

Base Information

Chemical Name:(S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile
CAS No.:1307869-48-2
Molecular Formula:C₂₄H₂₅N₃O₂S
Molecular Weight:419.547
Hs Code.:

Synonyms:(S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile

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Chemical Property of (S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile

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Technology Process of (S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile

There total 9 articles about (S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (S)-5-(5-(1-((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile

: 1307869-48-2
(S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃; for 12h;

Reference yield:

: 1307231-22-6
(S)-tert-butyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

: 1307869-48-2
(S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 12 h / 80 °C / Inert atmosphere

2: isopropyl alcohol / 4 h / 60 °C

3: hydrogenchloride / 1,4-dioxane / 2.5 h / 55 °C

4: triethylamine / N,N-dimethyl-formamide / 48 h / 100 °C

5: hydrogenchloride / diethyl ether / 12 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1307231-21-5
(S)-tert-butyl 4-bromo-2,3-dihydro-1H-inden-1-ylcarbamate

: 1307869-48-2
(S)-5-(5-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 12 h / 80 °C / Inert atmosphere

3: isopropyl alcohol / 4 h / 60 °C

4: hydrogenchloride / 1,4-dioxane / 2.5 h / 55 °C

5: triethylamine / N,N-dimethyl-formamide / 48 h / 100 °C

6: hydrogenchloride / diethyl ether / 12 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide; isopropyl alcohol;