benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate

Base Information

Chemical Name:benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate
CAS No.:103321-74-0
Molecular Formula:C₃₁H₃₆N₄O₆
Molecular Weight:560.65
Hs Code.:

benzyl (3S,5R)-<2-<<N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate

Synonyms:benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate

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Technology Process of benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate

There total 20 articles about benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5041-33-8
N-(Benzyloxycarbonyl)allylamine

: 103321-74-0
benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate

Guidance literature:: Multi-step reaction with 10 steps

1: toluene, reflux, 14 h

2: 10 percent HCl, MeOH / 4 h / 90 °C

3: K₂CO₃ / dimethylformamide / 1 h / 50 °C

4: LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

5: (iPr)2NEt, Et₃N / CH₂Cl₂ / 10 h / 0 - 25 °C

6: dimethylsulfoxide / rt., 2 h, than 50 deg C, 10 h

7: HCl / 12 h / 0 - 25 °C

8: 4 percent aq. NaOH/MeOH / 3 h / Ambient temperature

9: Et₃N / toluene / 0.42 h / 0 °C

10: toluene / 0 deg C, 2 h, than rt., 10 h

With hydrogenchloride; methanol; sodium hydroxide; lithium aluminium tetrahydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00275a064

Reference yield:

: 103321-70-6
(3R,5R)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(cyanomethyl)isoxazolidine

: 103321-74-0
benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / 12 h / 0 - 25 °C

2: 4 percent aq. NaOH/MeOH / 3 h / Ambient temperature

3: Et₃N / toluene / 0.42 h / 0 °C

4: toluene / 0 deg C, 2 h, than rt., 10 h

With hydrogenchloride; methanol; sodium hydroxide; triethylamine; In toluene;
DOI:10.1021/ja00275a064

Reference yield:

: 103321-68-2
(3S,5R)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

: 103321-74-0
benzyl (3S,5R)-<2-<methyl>isoxazolidin-3-yl>acetyl>-1-methylhydrazino>acetate

Guidance literature:: Multi-step reaction with 6 steps

1: (iPr)2NEt, Et₃N / CH₂Cl₂ / 10 h / 0 - 25 °C

2: dimethylsulfoxide / rt., 2 h, than 50 deg C, 10 h

3: HCl / 12 h / 0 - 25 °C

4: 4 percent aq. NaOH/MeOH / 3 h / Ambient temperature

5: Et₃N / toluene / 0.42 h / 0 °C

6: toluene / 0 deg C, 2 h, than rt., 10 h

With hydrogenchloride; methanol; sodium hydroxide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ja00275a064