sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

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Chemical Name:sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate
CAS No.:1286750-76-2
Molecular Formula:C₂₄H₂₃N₄O₄*Na
Molecular Weight:454.461
Hs Code.:

Synonyms:sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

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Chemical Property of sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

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Technology Process of sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

There total 9 articles about sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1286751-29-8
ethyl 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

: 1286750-76-2
sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 ℃; for 60h;
DOI:10.1021/ml2000214

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1286750-76-2
sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

2: pyridine / toluene / 2.33 h / 20 - 120 °C / Inert atmosphere

3: dichloromethane / 0 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 h / 20 °C

5: water; sodium hydroxide / ethanol / 60 h / 20 °C

With pyridine; oxalyl dichloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane; toluene; acetonitrile; 4: Michael addition;
DOI:10.1021/ml2000214

Reference yield:

: 226942-29-6
6-bromo-1,2,3,4-tetrahydroisoquinoline

: 1286750-76-2
sodium 3-(6-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydroisoquinolin-2(1H)-yl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation

2: triethylamine / dichloromethane / 1 h / 20 °C

3: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 80 °C

4: pyridine / toluene / 2.33 h / 20 - 120 °C / Inert atmosphere

5: dichloromethane / 0 - 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 h / 20 °C

7: water; sodium hydroxide / ethanol / 60 h / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 6: Michael addition;
DOI:10.1021/ml2000214