2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1201645-71-7
Molecular Formula:C₂₆H₂₅N₅O₂
Molecular Weight:439.517
Hs Code.:

Synonyms:2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

There total 16 articles about 2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201645-79-5
C₂₆H₂₈N₄O₂

: 1201645-71-7
2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With isopentyl nitrite; In toluene; at 80 ℃; for 18h;

Reference yield:

: 1201643-78-8
2-(4-(5-bromo-1-tosyl-1H-indol-3-carbonyl)phenyl)-2-methylpropanenitrile

: 1201645-71-7
2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

2: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

3: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

4: hydrogenchloride / acetone / 24 h

5: hydrogenchloride / water / 24 h

6: potassium acetate / ethanol / 5 h / Reflux

7: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 140 °C

8: hydrogen / nickel / tetrahydrofuran / 25 °C / 760.05 Torr

9: potassium acetate / toluene

10: isopentyl nitrite / toluene / 18 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; potassium acetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ozone; trifluoroacetic acid; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 40119-34-4
2-methyl-2-(4-methylphenyl)propionitrile

: 1201645-71-7
2-(4-(3-acetyl-8-morpholino-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 13 steps

1.1: pyridine; potassium permanganate / water / 1 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

3.2: 25 °C

4.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

5.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

6.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

7.1: hydrogenchloride / acetone / 24 h

8.1: hydrogenchloride / water / 24 h

9.1: potassium acetate / ethanol / 5 h / Reflux

10.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 140 °C

11.1: hydrogen / nickel / tetrahydrofuran / 25 °C / 760.05 Torr

12.1: potassium acetate / toluene

13.1: isopentyl nitrite / toluene / 18 h / 80 °C

With pyridine; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; hydrogen; potassium acetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ozone; N,N-dimethyl-formamide; trifluoroacetic acid; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;