tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate

Base Information

• Chemical Name: tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate
• CAS No.: 1018450-35-5
• Molecular Formula: C₁₁H₁₂ClFINO₂
• Molecular Weight: 371.578

Synonyms:tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate

Chemical Property of tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(4-chloro-3-fluoro-2-iodophenyl)carbamate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate

There total 6 articles about tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,1-dimethylethyl (4-chloro-3-fluorophenyl)carbamate (869299-68-3) → tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate (1018450-35-5)

Guidance literature:

1,1-dimethylethyl (4-chloro-3-fluorophenyl)carbamate; With n-butyllithium; In tetrahydrofuran; at -80 - 75 ℃; for 2.66667h;

With iodine; In tetrahydrofuran; at -80 - 35 ℃; for 17h;

Reference yield: 44.0%

1,1-dimethylethyl (4-chloro-3-fluorophenyl)carbamate (869299-68-3) → tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate (1018450-35-5) + 6-chloro-7-iodo-2(3H)-benzoxazolone (1242560-17-3)

Guidance literature:

1,1-dimethylethyl (4-chloro-3-fluorophenyl)carbamate; With n-butyllithium; In tetrahydrofuran; hexane; at -72 - -68 ℃; for 4h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; at -72 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1021/op1001808

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate (1018450-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-heptane / 4 h / 90 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 2.67 h / -80 - -75 °C / Inert atmosphere

2.2: 17 h / -80 - -30 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane; n-heptane;

DOI:10.1021/op1001808

upstream raw materials:

1,1-dimethylethyl (4-chloro-3-fluorophenyl)carbamate

di-tert-butyl dicarbonate

4-chloro-3-fluoroaniline

Downstream raw materials:

4-chloro-3-fluoro-2-iodoaniline

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