(2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol

Base Information

Chemical Name:(2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol
CAS No.:1384986-42-8
Molecular Formula:C₁₉H₂₇NO₅
Molecular Weight:349.427
Hs Code.:

Synonyms:(2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol

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Chemical Property of (2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol

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Technology Process of (2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol

There total 3 articles about (2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1202776-24-6
(2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane

: 1384986-42-8
(2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol

Guidance literature:: With acetic acid; zinc; In tetrahydrofuran; water; at 60 ℃; for 4h;
DOI:10.1016/j.tet.2012.05.126

Reference yield:

: 1202776-15-5
C₁₉H₂₇NO₅

: 1384986-42-8
(2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: manganese(IV) oxide / dichloromethane / 6 h / 0 °C / Inert atmosphere

2: toluene / 72 h / 100 °C / Sealed vessel

3: acetic acid; zinc / tetrahydrofuran; water / 4 h / 60 °C

With manganese(IV) oxide; acetic acid; zinc; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1016/j.tet.2012.05.126

Reference yield:

: 1202776-19-9
(R,Z)-N-benzylidene-1-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)but-3-en-1-amine oxide

: 1384986-42-8
(2R,4S,6S)-2-((3aS,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenylpiperidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 72 h / 100 °C / Sealed vessel

2: acetic acid; zinc / tetrahydrofuran; water / 4 h / 60 °C

With acetic acid; zinc; In tetrahydrofuran; water; toluene;
DOI:10.1016/j.tet.2012.05.126