tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate
CAS No.:1613169-09-7
Molecular Formula:C₂₅H₂₉BrF₃N₃O₄
Molecular Weight:572.422
Hs Code.:

Synonyms:tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate

There total 2 articles about tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1878-91-7
(4-bromophenoxy)acetic acid

: 859027-30-8
4-(4-amino-2-trifluoromethyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1613169-09-7
tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate

Guidance literature:: (4-bromophenoxy)acetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 1h;

4-(4-amino-2-trifluoromethyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1021/acs.jmedchem.5b01712

Reference yield:

: 1613169-09-7
tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 754214-56-7
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 1613169-09-7
tert-butyl 4-(4-(2-(4-bromophenoxy)acetamido)-2-(trifluoromethyl)benzyl)piperazine-1-carboxylate

: C₃₂H₃₄F₃N₅O₄

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 100 ℃; for 16h;