2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide

Base Information

• Chemical Name: 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide
• CAS No.: 1562665-78-4
• Molecular Formula: C₂₄H₂₂ClN₃O₅S₃
• Molecular Weight: 564.107

Synonyms:2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide

Chemical Property of 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide

Chemical Property:

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Technology Process of 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide

There total 6 articles about 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-[(3,5-dimethylphenyl)sulfonyl]-1,3-dihydro-2Hbenzimidazole-2-thione (1562664-75-8) + 2-chloro-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide (1562667-03-1) → 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide (1562665-78-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2013.12.045

Reference yield:

2-nitro-aniline (88-74-4) → 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide (1562665-78-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2: hydrogenchloride; zinc / ethanol / 1 h / Reflux

3: pyridine / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; zinc; In pyridine; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.12.045

Reference yield:

3,5-dimethyl-benzenesulfonyl chloride (2905-27-3) → 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-[2-chloro-4-(methylsulfonyl)phenyl]acetamide (1562665-78-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2: hydrogenchloride; zinc / ethanol / 1 h / Reflux

3: pyridine / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; zinc; In pyridine; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.12.045

upstream raw materials:

2-nitro-aniline

3,5-dimethyl-benzenesulfonyl chloride

N-(2-nitrophenyl)-3,5-dimethylbenzenesulfonamide

2-chloro-4-(methylsulfonyl)aniline

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