1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Name:1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea
CAS No.:1610449-55-2
Molecular Formula:C₄₂H₄₄F₃N₇O₇
Molecular Weight:815.849
Hs Code.:

1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Synonyms:1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Property of 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Technology Process of 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

There total 10 articles about 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562518-34-6
1-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea

: 1610450-37-7
3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)aniline

: 1610449-55-2
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 70 ℃; for 18h;

Reference yield:

: 1163141-52-3
3-hydroxy-5-(trifluoromethoxy)benzoic acid

: 1610449-55-2
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: chloro-trimethyl-silane / 3 h / Reflux

2: sodium iodide; potassium carbonate / acetonitrile / 6 h / Reflux

3: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

4: triethylamine; diphenyl phosphoryl azide / 18 h / Reflux

5: hydrogenchloride / isopropyl alcohol / 5 h / 20 °C

6: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 18 h / 70 °C

With hydrogenchloride; chloro-trimethyl-silane; diphenyl phosphoryl azide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1610450-34-4
3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)benzoic acid

: 1610449-55-2
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-5-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; diphenyl phosphoryl azide / 18 h / Reflux

2: hydrogenchloride / isopropyl alcohol / 5 h / 20 °C

3: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 18 h / 70 °C

With hydrogenchloride; diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol;