O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine

Base Information

Chemical Name:O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine
CAS No.:62763-03-5
Molecular Formula:C₂₁H₂₂ClN₅O
Molecular Weight:395.892
Hs Code.:

<i>O</i>-(8-chloro-6-phenyl-4<i>H</i>-benzo[<i>f</i>][1,2,4]triazolo[4,3-<i>a</i>][1,4]diazepin-1-ylmethyl)-<i>N</i>,<i>N</i>-diethyl-hydroxylamine

Synonyms:O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine

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Technology Process of O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine

There total 4 articles about O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.3%

: 64420-61-7
C₂₁H₂₂ClN₅O

: 62763-04-6
8-chloro-1-<(ethylhydroxyamino)methyl>-6-phenyl-4H-s-triazolo<4,3-a><1,4>benzodiazepine

: 62763-03-5
O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine

Guidance literature:: at 112 - 151 ℃; for 0.716667h; under 23 Torr;
DOI:10.1021/jm00178a009

Reference yield:

: Chloro-acetic acid N'-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-hydrazide

: 62763-03-5
O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 0.33 h / Heating

2: 1.) NaH / 1.) DMF, 25 dec C, 1 h, 2.) DMF, RT, 2 h

3: 51.3 percent / 0.72 h / 112 - 151 °C / 23 Torr

With sodium hydride; In acetic acid;
DOI:10.1021/jm00178a009

Reference yield:

: 18091-89-9,112393-62-1
7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

: 62763-03-5
O-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-N,N-diethyl-hydroxylamine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1.58 h / 0 - 20 °C

2: acetic acid / 0.33 h / Heating

3: 1.) NaH / 1.) DMF, 25 dec C, 1 h, 2.) DMF, RT, 2 h

4: 51.3 percent / 0.72 h / 112 - 151 °C / 23 Torr

With sodium hydride; In tetrahydrofuran; acetic acid;
DOI:10.1021/jm00178a009