8-Chloroquinolin-2-amine

Base Information

• Chemical Name: 8-Chloroquinolin-2-amine
• CAS No.: 343868-74-6
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.621
• Hs Code.: 2933499090
• European Community (EC) Number: 870-995-1
• DSSTox Substance ID: DTXSID40507427
• Wikidata: Q82363654
• Mol file: 343868-74-6.mol

Synonyms:8-CHLOROQUINOLIN-2-AMINE;343868-74-6;SCHEMBL13906830;DTXSID40507427;AMY26468;MFCD08272075;AKOS013465662;AB44300;AS-41334;CS-0197167;FT-0765817;EN300-129334;A850475;Z1198176742

Chemical Property of 8-Chloroquinolin-2-amine

Chemical Property:

• Boiling Point: 340.5±22.0 °C(Predicted)
• PKA: 3.97±0.50(Predicted)
• PSA: 38.91000
• Density: 1.363±0.06 g/cm3(Predicted)
• LogP: 3.05160
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 178.0297759
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

97% ^*data from raw suppliers

8-chloroquinolin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)Cl)N=C(C=C2)N

Technology Process of 8-Chloroquinolin-2-amine

There total 1 articles about 8-Chloroquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-bromo-8-chloro-quinoline (891842-52-7) → 2-amino-8-chloro-quinoline (343868-74-6)

Guidance literature:

With copper acetylacetonate; potassium phosphate; ammonia; In N,N-dimethyl-formamide; at 90 ℃; for 24h; chemoselective reaction; Glovebox; Autoclave;

DOI:10.1002/adsc.201201010

upstream raw materials:

2-bromo-8-chloro-quinoline