4-chloro-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidine

Base Information

• Chemical Name: 4-chloro-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidine
• CAS No.: 1018481-23-6
• Molecular Formula: C₁₂H₈ClF₃N₂S
• Molecular Weight: 304.723
• Mol file: 1018481-23-6.mol

Synonyms:4-chloro-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidine

Chemical Property of 4-chloro-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidine

Chemical Property:

Purity/Quality:

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Technology Process of 4-chloro-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidine

There total 1 articles about 4-chloro-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidin-4-ol (1018481-16-7) → 4-chloro-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidine (1018481-23-6)

Guidance literature:

With trichlorophosphate; at 20 - 90 ℃; for 1h;

DOI:10.1016/j.bmc.2007.11.079

Reference yield: 93.0%

4-chloro-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidine (1018481-23-6) → 4-chloro-2-(4-methanesulfonylphenyl)-6-trifluoromethylpyrimidine (1018481-30-5)

Guidance literature:

With Oxone; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1016/j.bmc.2007.11.079

upstream raw materials:

2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidin-4-ol

Downstream raw materials:

4-chloro-2-(4-methanesulfonylphenyl)-6-trifluoromethylpyrimidine