2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide

Base Information

Chemical Name:2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide
CAS No.:1410044-63-1
Molecular Formula:C₂₆H₃₀F₃NOS
Molecular Weight:461.592
Hs Code.:

Synonyms:2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide

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Chemical Property of 2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide

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Technology Process of 2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide

There total 2 articles about 2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 566938-58-7
1-(3-iodopropyl)-3-(trifluoromethyl)benzene

: 1278586-89-2
(R,R)-2-methylpropane-2-sulfinic acid 1-(naphthalen-1-yl)ethylamide

: 1410044-63-1
2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide

Guidance literature:: (R,R)-2-methylpropane-2-sulfinic acid 1-(naphthalen-1-yl)ethylamide; With lithium hexamethyldisilazane; In N,N-dimethyl-formamide; at 20 ℃; for 1.16667h; Inert atmosphere;

1-(3-iodopropyl)-3-(trifluoromethyl)benzene; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 6.25h; regioselective reaction; Inert atmosphere;
DOI:10.3762/bjoc.8.158

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 1410044-63-1
2-methylpropane-2-sulfinic acid (1-naphthalen-1-ylethyl)-[3-(3-trifluoromethylphenyl)propyl]amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; piperidine / 4.25 h / 20 - 120 °C / Inert atmosphere

1.2: pH 2

2.1: sodium hydroxide / water / 20 °C

2.2: 7 h / 25 - 30 °C / 750.08 Torr

2.3: pH 2

3.1: thionyl chloride / 4 h / Inert atmosphere; Reflux

4.1: sodium tetrahydroborate / tetrahydrofuran / Inert atmosphere; Reflux

4.2: 9 h / 60 - 65 °C / Inert atmosphere

5.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 2 h / 20 - 35 °C

6.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / 1.17 h / 20 °C / Inert atmosphere

6.2: 6.25 h / 20 °C / Inert atmosphere

With piperidine; pyridine; 1H-imidazole; sodium tetrahydroborate; thionyl chloride; iodine; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3762/bjoc.8.158