ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate

Base Information

• Chemical Name: ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate
• CAS No.: 760981-55-3
• Molecular Formula: C₂₄H₂₁N₃O₆S
• Molecular Weight: 479.513
• Mol file: 760981-55-3.mol

Synonyms:ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate

Chemical Property of ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate

There total 5 articles about ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

{4-[2-(4-hydroxymethyl-1H-benzoimidazol-2-yl)-phenylsulfamoyl]-phenoxy}-acetic acid ethyl ester (867339-08-0) → ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate (760981-55-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

DOI:10.1002/chem.200305299

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) → ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate (760981-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 2 h / 20 °C

2: 36 percent / aq. Cu(OAc)2 / methanol; ethanol / 3 h / Heating

3: 86 percent / MnO₂ / CH₂Cl₂ / 20 °C

With pyridine; manganese(IV) oxide; copper diacetate; In methanol; ethanol; dichloromethane;

DOI:10.1002/chem.200305299

Reference yield:

phenoxyacetic acid ethyl ester (2555-49-9) → ethyl {4-[2-(4-formyl-1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate (760981-55-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / chlorosulfonic acid / CH₂Cl₂ / 3 h / 20 °C

2: pyridine / CH₂Cl₂ / 2 h / 20 °C

3: 36 percent / aq. Cu(OAc)2 / methanol; ethanol / 3 h / Heating

4: 86 percent / MnO₂ / CH₂Cl₂ / 20 °C

With pyridine; chlorosulfonic acid; manganese(IV) oxide; copper diacetate; In methanol; ethanol; dichloromethane;

DOI:10.1002/chem.200305299

upstream raw materials:

{4-[2-(4-hydroxymethyl-1H-benzoimidazol-2-yl)-phenylsulfamoyl]-phenoxy}-acetic acid ethyl ester

2-Aminobenzyl alcohol

phenoxyacetic acid ethyl ester

(4-chlorosulfonyl-phenoxy)acetic acid ethyl ester

Downstream raw materials:

ethyl {4-{2-{4-[(methylpyridin-2-ylmethylamino)methyl]-1H-benzimidazol-2-yl}phenylsulfamoyl}phenoxy}acetate

ethyl {4-{2-{4-[(bispyridin-2-ylmethylamino)methyl]-1H-benzimidazol-2-yl}phenylsulfamoyl}phenoxy}acetate

ethyl {4-{2-{4-[(diethylamino)methyl]-1H-benzimidazol-2-yl}phenylsulfamoyl}phenoxy}acetate