(2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester

Base Information

Chemical Name:(2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester
CAS No.:115757-26-1
Molecular Formula:C₁₉H₃₀O₃S
Molecular Weight:338.511
Hs Code.:

Synonyms:(2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester

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Technology Process of (2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester

There total 1 articles about (2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 79027-28-4
(2S)-3-(benzyloxy)-2-methylpropanal

: 115757-24-9
tert-Butyl-((E)-1-tert-butylsulfanyl-but-1-enyloxy)-dimethyl-silane

: 115757-26-1
(2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -80 - -78 ℃; for 1.5h;
DOI:10.1021/jo00252a025

Reference yield: 85.0%

: 115757-26-1
(2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester

: 115795-62-5
(2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanoic acid

Guidance literature:: With mercury(II) trifluoroacetate; In water; acetonitrile; at 60 - 65 ℃; for 6h;
DOI:10.1021/jo00252a025

Reference yield:

: 115757-26-1
(2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanethioic acid S-tert-butyl ester

: 115757-22-7
(3R,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-ethyl-1-methoxy-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / Hg(OCOCF₃)2 / acetonitrile; H₂O / 6 h / 60 - 65 °C

2: 70 percent / 2N aq. HCl, N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide / tetrahydrofuran / 5 h / Ambient temperature

3: pyridine / 3 h / 0 °C

4: K₂CO₃ / acetone / 1 h / Heating

With pyridine; hydrogenchloride; mercury(II) trifluoroacetate; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; water; acetone; acetonitrile;
DOI:10.1021/jo00252a025