[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid

Base Information

• Chemical Name: [3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid
• CAS No.: 920509-19-9
• Molecular Formula: C₁₅H₁₃Br₂ClN₂O₃
• Molecular Weight: 464.541

Synonyms:[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid

Chemical Property of [3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid

Chemical Property:

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Technology Process of [3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid

There total 3 articles about [3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]ethanol (920509-18-8) → [3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid (920509-19-9)

Guidance literature:

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In dichloromethane; water; acetonitrile; at 20 - 40 ℃; for 1.25h; pH=6.7; Sodium phosphate buffer;

Reference yield:

2,6-dibromo-4-(2-hydroxy-ethyl)-phenol → [3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid (920509-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / N,N-dimethyl acetamide / 24 h / 20 - 135 °C

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite; sodium hypochlorite / water; acetonitrile; dichloromethane; aq. phosphate buffer / 0.75 h / 20 - 40 °C / pH 6.7

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; In aq. phosphate buffer; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

DOI:10.1021/jm4019299

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) → [3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]acetic acid (920509-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid; bromine / 20 °C

1.2: 3 h / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl acetamide / 24 h / 20 - 135 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite; sodium hypochlorite / water; acetonitrile; dichloromethane; aq. phosphate buffer / 0.75 h / 20 - 40 °C / pH 6.7

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; bromine; acetic acid; In aq. phosphate buffer; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

DOI:10.1021/jm4019299

upstream raw materials:

2-[3,5-dibromo-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]ethanol

p-hydroxyphenethyl alcohol

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