benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester

Base Information

Chemical Name:benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester
CAS No.:125760-11-4
Molecular Formula:C₅₄H₇₅F₅N₄O₁₅
Molecular Weight:1115.2
Hs Code.:

benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester

Synonyms:benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester

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Chemical Property of benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester

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Technology Process of benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester

There total 10 articles about benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid

: 125760-11-4
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1016/0040-4020(95)00962-0

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 125760-11-4
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / DCC, dimethylaminopyridine / CH₂Cl₂ / 24 h / Ambient temperature

2: 99 percent / H₂ / 10percent Pd/C / methanol / 5 h / Ambient temperature

3: 81 percent / DCC, dimethylaminopyridine, N-methylmorpholine / CH₂Cl₂ / 12 h / Ambient temperature

4: 99 percent / TFA / CH₂Cl₂ / 8 h / 0 °C

5: 69 percent / DCC, dimethylaminopyridine, N-methylmorpholine / CH₂Cl₂ / 16 h / Ambient temperature

6: 87 percent / TFA / CH₂Cl₂ / 3 h / Ambient temperature

7: 70 percent / DCC, dimethylaminopyridine / CH₂Cl₂ / 15 h / Ambient temperature

With 4-methyl-morpholine; dmap; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/0040-4020(95)00962-0

Reference yield:

: 3519-30-0
L-α-hydroxyisovaleric acid t-butyl ester

: 125760-11-4
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleryl-L-valyl-L-α-hydroxyisovaleric acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / DCC, dimethylaminopyridine / CH₂Cl₂ / 24 h / Ambient temperature

2: 99 percent / H₂ / 10percent Pd/C / methanol / 5 h / Ambient temperature

3: 81 percent / DCC, dimethylaminopyridine, N-methylmorpholine / CH₂Cl₂ / 12 h / Ambient temperature

4: 99 percent / TFA / CH₂Cl₂ / 8 h / 0 °C

5: 69 percent / DCC, dimethylaminopyridine, N-methylmorpholine / CH₂Cl₂ / 16 h / Ambient temperature

6: 87 percent / TFA / CH₂Cl₂ / 3 h / Ambient temperature

7: 70 percent / DCC, dimethylaminopyridine / CH₂Cl₂ / 15 h / Ambient temperature

With 4-methyl-morpholine; dmap; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/0040-4020(95)00962-0