Benzofuran, 2-(2S)-oxiranyl- (9CI)

Base Information

• Chemical Name: Benzofuran, 2-(2S)-oxiranyl- (9CI)
• CAS No.: 343614-08-4
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.172
• Mol file: 343614-08-4.mol

Synonyms:Benzofuran,2-(2S)-oxiranyl- (9CI)

Chemical Property of Benzofuran, 2-(2S)-oxiranyl- (9CI)

Chemical Property:

• PSA: 25.67000
• LogP: 2.50410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzofuran, 2-(2S)-oxiranyl- (9CI)

There total 3 articles about Benzofuran, 2-(2S)-oxiranyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(-)-1-(benzofuran-2-yl)-2-bromoethanol (343614-07-3) → (S)-(-)-(benzofuran-2-yl)oxirane (343614-08-4) + (R)-2-Oxiranyl-benzofuran

Guidance literature:

With sodium hydroxide; In diethyl ether; pentane; at 20 ℃; for 3h; Title compound not separated from byproducts;

DOI:10.3987/COM-00-9143

Reference yield:

1-(benzo[b]furan-2-yl)ethanone (1646-26-0) → (S)-(-)-(benzofuran-2-yl)oxirane (343614-08-4)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; aluminum chloride / CH₂Cl₂

2: 11.60 g / (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 27 h / -30 - -5 °C

3: aq. NaOH / diethyl ether; pentane / 3 h / 20 °C

With sodium hydroxide; aluminium trichloride; bromine; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; diethyl ether; dichloromethane; pentane;

DOI:10.3987/COM-00-9143

Reference yield:

1-(benzofuran-2-yl)-2-bromoethan-1-one (23489-36-3) → (S)-(-)-(benzofuran-2-yl)oxirane (343614-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 11.60 g / (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 27 h / -30 - -5 °C

2: aq. NaOH / diethyl ether; pentane / 3 h / 20 °C

With sodium hydroxide; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; diethyl ether; pentane;

DOI:10.3987/COM-00-9143

upstream raw materials:

(R)-(-)-1-(benzofuran-2-yl)-2-bromoethanol

1-(benzo[b]furan-2-yl)ethanone

1-(benzofuran-2-yl)-2-bromoethan-1-one

Refernces