3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Base Information

Chemical Name:3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid
CAS No.:866110-75-0
Molecular Formula:C₃₃H₄₁NO₇Si
Molecular Weight:591.777
Hs Code.:

3-[5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Synonyms:3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

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Chemical Property of 3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

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Technology Process of 3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

There total 1 articles about 3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propionic acid

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 866110-75-0
3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ja0535918

Reference yield:

: 866110-75-0
3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

: {2-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-1-chlorocarbonyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.1021/ja0535918

Reference yield:

: 866110-75-0
3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

: 866110-78-3
(1R,3S,6R,11aS)-7-Allyloxy-6-allyloxymethyl-1-hydroxy-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-8,10-dimethoxy-9-methyl-4-oxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 0.33 h / 20 °C

2: 123 mg / 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

3: 86 mg / piperidine / CH₂Cl₂ / 6 h / 20 °C

4: 96 mg / ethanol / 12 h / 20 °C

5: 81 mg / aq. HCO₂H / tetrahydrofuran / 0.75 h / 20 °C

6: 79 mg / Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 2.5 h / 20 °C

7: 68 mg / TBAF / tetrahydrofuran / 0.58 h / 0 °C

With piperidine; 2,6-dimethylpyridine; formic acid; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; Dess-Martin periodane; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja0535918