(2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate

Base Information

Chemical Name:(2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate
CAS No.:1359827-70-5
Molecular Formula:C₁₆H₁₇NO₇
Molecular Weight:335.313
Hs Code.:

Synonyms:(2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate

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Chemical Property of (2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate

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Technology Process of (2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate

There total 3 articles about (2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1504-65-0
3-(2-nitrophenyl)prop-2-en-1-ol

: 685-87-0
Diethyl 2-bromomalonate

: 1359827-70-5
(2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate

Guidance literature:: With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 7h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chem.201102551

Reference yield:

: 1466-88-2,66894-06-2
2-nitrocinnamic aldehyde

: 685-87-0
Diethyl 2-bromomalonate

: 1359827-70-5
(2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate

Guidance literature:: With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; In chloroform; at 20 ℃;
DOI:10.1002/anie.202110719

Reference yield:

: 1466-88-2,66894-06-2
2-nitrocinnamic aldehyde

: 14064-10-9
diethyl 2-chloromalonate

: 1359827-70-5
(2R,3S)-diethyl 2-formyl-3-(2-nitrophenyl)-cyclopropane-1,1-dicarboxylate

: diethyl (2S,3R)-2-formyl-3-(2-nitrophenyl)cyclopropane-1,1-dicarboxylate

Guidance literature:: With 4-oxalocrotonate tautomerase variant M₄₅V/F₅₀A; In acetonitrile; at 18 ℃; for 71h; pH=6.2; Overall yield = 19 percent; Overall yield = 10 mg; stereoselective reaction; Inert atmosphere; Enzymatic reaction;
DOI:10.1002/anie.202110719