6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

Base Information

Chemical Name:6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde
CAS No.:798565-02-3
Molecular Formula:C₂₄H₂₇NO₆
Molecular Weight:425.481
Hs Code.:

Synonyms:6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

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Chemical Property of 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

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Technology Process of 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

There total 8 articles about 6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 798565-01-2
6-(3-acetoxy-propoxy)-4-formyl-7-methoxy-1-(3-methoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester

: 798565-02-3
6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

Guidance literature:: With potassium hydroxide; In methanol; at 20 ℃; for 3h;

Reference yield:

: [1-(4-benzyloxy-3-methoxy-phenyl)-2-(3-methoxy-phenyl)-ethyl]-(2,2-dimethoxy-ethyl)-amine

: 798565-02-3
6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / tetrahydrofuran; water / 1 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 15 h / 760.05 Torr

3.1: potassium carbonate / acetone / 18 h / 85 °C

4.1: hydrogenchloride / water; acetone / 15 h / 0 - 20 °C

5.1: pyridine / 15 h / 20 °C

6.1: trichlorophosphate / 0.5 h / 0 - 20 °C

6.2: 4 h / 0 - 80 °C

6.3: 0.33 h / 0 - 80 °C

7.1: potassium hydroxide / methanol / 3 h / 20 °C

With hydrogenchloride; potassium hydroxide; hydrogen; potassium carbonate; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; water; ethyl acetate; acetone;

Reference yield:

: [1-(4-benzyloxy-3-methoxy-phenyl)-2-(3-methoxy-phenyl)-ethyl]-(2,2-dimethoxy-ethyl)-carbamic acid ethyl ester

: 798565-02-3
6-(3-acetoxy-propoxy)-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 15 h / 760.05 Torr

2.1: potassium carbonate / acetone / 18 h / 85 °C

3.1: hydrogenchloride / water; acetone / 15 h / 0 - 20 °C

4.1: pyridine / 15 h / 20 °C

5.1: trichlorophosphate / 0.5 h / 0 - 20 °C

5.2: 4 h / 0 - 80 °C

5.3: 0.33 h / 0 - 80 °C

6.1: potassium hydroxide / methanol / 3 h / 20 °C

With hydrogenchloride; potassium hydroxide; hydrogen; potassium carbonate; trichlorophosphate; palladium 10% on activated carbon; In pyridine; methanol; water; ethyl acetate; acetone;