1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate

Base Information

Chemical Name:1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate
CAS No.:1314808-21-3
Molecular Formula:C₂₇H₄₃NO₅Si
Molecular Weight:489.728
Hs Code.:

Synonyms:1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate

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Chemical Property of 1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate

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Technology Process of 1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate

There total 5 articles about 1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1314808-20-2
tert-butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)(2-hydroxy-6-phenylhex-3-yn-1-yl)carbamate

: 108-24-7
acetic anhydride

: 1314808-21-3
1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.115

Reference yield:

: 1215265-39-6
tert-butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)(2-hydroxyethyl)carbamate

: 1314808-21-3
1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

1.2: 1.25 h / -78 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexanes; dichloromethane;
DOI:10.1016/j.tet.2011.03.115

Reference yield:

: 1314808-19-9
tert-butyl N-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-N-(2-oxoethyl)carbamate

: 1314808-21-3
1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; n-butyllithium; triethylamine; In tetrahydrofuran; hexanes; dichloromethane;
DOI:10.1016/j.tet.2011.03.115