(R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide

Base Information

Chemical Name:(R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide
CAS No.:1366298-54-5
Molecular Formula:C₁₇H₂₂F₂N₄O₅S
Molecular Weight:432.448
Hs Code.:

Synonyms:(R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide

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Chemical Property of (R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide

Chemical Property:

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Technology Process of (R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide

There total 7 articles about (R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365998-57-7
4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile

: 1366298-54-5
(R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide

Guidance literature:: With hydroxylamine; In ethanol; at 60 ℃;

Reference yield:

: 1351168-97-2
tert-butyl 4-(3-bromo-2-oxo-pyrrolidin-1-yl)piperidine-1-carboxylate

: 1366298-54-5
(R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 20 °C

2: trans-1,2-cyclohexanediamine; copper(I) trifluoromethanesulfonate benzene / dimethyl sulfoxide / 110 °C / Inert atmosphere

3: hydrogenchloride / ethyl acetate; isopropyl alcohol / 0 - 20 °C

4: potassium carbonate / acetonitrile / 20 °C

5: hydroxylamine / ethanol / 60 °C

With hydrogenchloride; hydroxylamine; potassium carbonate; copper(I) trifluoromethanesulfonate benzene; trans-1,2-cyclohexanediamine; In ethanol; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1366298-54-5
(R,E)-4-(3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)-N'-hydroxypiperidine-1-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 0 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3: potassium carbonate / acetone / 20 °C

4: trans-1,2-cyclohexanediamine; copper(I) trifluoromethanesulfonate benzene / dimethyl sulfoxide / 110 °C / Inert atmosphere

5: hydrogenchloride / ethyl acetate; isopropyl alcohol / 0 - 20 °C

6: potassium carbonate / acetonitrile / 20 °C

7: hydroxylamine / ethanol / 60 °C

With hydrogenchloride; hydroxylamine; sodium hydride; potassium carbonate; triethylamine; copper(I) trifluoromethanesulfonate benzene; trans-1,2-cyclohexanediamine; In ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetone; acetonitrile; mineral oil;