ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

Base Information

Chemical Name:ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate
CAS No.:1159611-62-7
Molecular Formula:C₄₂H₆₀O₈Si₂
Molecular Weight:749.105
Hs Code.:

ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

Synonyms:ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

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Chemical Property of ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

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Technology Process of ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

There total 8 articles about ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1028481-73-3
ethyl (R)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

: 1159611-62-7
ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

Guidance literature:: ethyl (R)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate; With sodium hydrogencarbonate; ozone; In dichloromethane; at -78 ℃; for 0.0166667h;

With triphenylphosphine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ol900585t

Reference yield:

: 1028481-69-7
ethyl (R)-4-((2R,6S)-6-((S)-4-(hydroxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)-3-hydroxy-butanoate

: 1159611-62-7
ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane; methanol / 12 h / 20 °C

2: triethylamine / dichloromethane / 12 h / 20 °C

3: sodium hydrogencarbonate; ozone / dichloromethane / 0.02 h / -78 °C

With dmap; sodium hydrogencarbonate; ozone; triethylamine; In methanol; dichloromethane;

Reference yield:

: C₁₃H₂₈O₄Si

: 1159611-62-7
ethyl (R)-4-((2S,6R)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-oxotetrahydro-2H-pyran-2-yl)-3-(trimethylsilyloxy)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / -5 °C / Inert atmosphere

1.2: 1 h / -5 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / diethyl ether / 1 h / -78 °C / Inert atmosphere

3.1: water; toluene-4-sulfonic acid / methanol; benzene / 5 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

5.1: sodium hydrogencarbonate; ozone / dichloromethane / 0.02 h / -78 °C

5.2: -78 - 20 °C

With trimethylsilyl trifluoromethanesulfonate; water; sodium hydrogencarbonate; toluene-4-sulfonic acid; ozone; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; benzene;