1,3-diamino-2-trifluoromethylbenzene

Base Information

• Chemical Name: 1,3-diamino-2-trifluoromethylbenzene
• CAS No.: 106877-25-2
• Molecular Formula: C₇H₇F₃N₂
• Molecular Weight: 176.141
• Mol file: 106877-25-2.mol

Synonyms:1,3-diamino-2-trifluoromethylbenzene

Chemical Property of 1,3-diamino-2-trifluoromethylbenzene

Chemical Property:

• Boiling Point: 269.5±35.0 °C(Predicted)
• Density: 1.381±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-diamino-2-trifluoromethylbenzene

There total 2 articles about 1,3-diamino-2-trifluoromethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

Bromotrifluoromethane (75-63-8) + m-phenylenediamine (108-45-2,64554-26-3,76583-20-5) → 1,3-diamino-4-trifluoromethylbenzene (17139-64-9) + 1,3-diamino-2-trifluoromethylbenzene (106877-25-2) + 1,5-diamino-2,4-bis(trifluoromethyl)benzene (106877-24-1) + 1,3-diamino-2,4-bis(trifluoromethyl)benzene (106877-23-0)

Guidance literature:

With 2,6-dimethylpyridine; sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 2h; under 2250.2 - 3750.3 Torr;

Reference yield:

C7H6BrF3N2 (1006384-64-0) → 1,3-diamino-2-trifluoromethylbenzene (106877-25-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 750.075 Torr;

Reference yield: 54.2%

dichloroacethyl chloride (79-36-7) + 1,3-diamino-2-trifluoromethylbenzene (106877-25-2) → N,N'-(2-(trifluoromethyl)-1,4-phenylene)bis(2,2-dichloroacetamide)

Guidance literature:

1,3-diamino-2-trifluoromethylbenzene; With triethylamine; In dichloromethane; Cooling with ice;

dichloroacethyl chloride; In dichloromethane; Cooling with ice;

DOI:10.1021/acs.jmedchem.5b01828

upstream raw materials:

Bromotrifluoromethane

m-phenylenediamine

C₇H₆BrF₃N₂

Downstream raw materials:

C₉H₃F₃N₂S₂