(alphaR)-1,3-Dihydro-1,3-dioxo-alpha-(phenylmethyl)-2H-isoindole-2-acetaldehyde

Base Information

Chemical Name:(alphaR)-1,3-Dihydro-1,3-dioxo-alpha-(phenylmethyl)-2H-isoindole-2-acetaldehyde
CAS No.:166734-67-4
Molecular Formula:C₁₇H₁₃NO₃
Molecular Weight:279.295
Hs Code.:
DSSTox Substance ID:DTXSID601150985

Synonyms:SCHEMBL8075909;DTXSID601150985;(alphaR)-1,3-Dihydro-1,3-dioxo-alpha-(phenylmethyl)-2H-isoindole-2-acetaldehyde;166734-67-4

Suppliers and Price of (alphaR)-1,3-Dihydro-1,3-dioxo-alpha-(phenylmethyl)-2H-isoindole-2-acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (alphaR)-1,3-Dihydro-1,3-dioxo-alpha-(phenylmethyl)-2H-isoindole-2-acetaldehyde

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:279.08954328
Heavy Atom Count:21
Complexity:404

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(C=O)N2C(=O)C3=CC=CC=C3C2=O
Isomeric SMILES:C1=CC=C(C=C1)C[C@H](C=O)N2C(=O)C3=CC=CC=C3C2=O

Technology Process of (alphaR)-1,3-Dihydro-1,3-dioxo-alpha-(phenylmethyl)-2H-isoindole-2-acetaldehyde

There total 4 articles about (alphaR)-1,3-Dihydro-1,3-dioxo-alpha-(phenylmethyl)-2H-isoindole-2-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 152903-44-1
(+)-(R)-2-(1-benzyl-2-hydroxyethyl)-1H-isoindole-1,3(2H)-dione

: 166734-67-4
(R)-2-phthalimido-3-phenylpropionaldehyde

Guidance literature:: With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 1.5h;
DOI:10.1080/00304940509354985

Reference yield:

: 32150-92-8
(R)-2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoyl chloride

: 166734-67-4
(R)-2-phthalimido-3-phenylpropionaldehyde

Guidance literature:: With hydrogen; Pd-BaSO₄; In toluene; for 10h;

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 166734-67-4
(R)-2-phthalimido-3-phenylpropionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 6 h / 140 - 150 °C

2: 65 percent / sulfur trioxide-pyridine complex; NEt₃ / dimethylsulfoxide; CH₂Cl₂ / 1.5 h / 20 °C

With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1080/00304940509354985