1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione

Base Information

• Chemical Name: 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione
• CAS No.: 321918-14-3
• Molecular Formula: C₁₅H₁₇N₃O₃
• Molecular Weight: 287.318

Synonyms:1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione

Chemical Property of 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione

There total 2 articles about 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2',3',4',5',6',7'-hexahydro-6'-imino-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]-diazepine)-3',7'-dione (321918-08-5) → 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione (321918-14-3)

Guidance literature:

at 180 - 230 ℃; for 1h; under 3.75038E-05 Torr;

DOI:10.1021/ol0068187

Reference yield:

9-chloro-4-(4-methoxy-benzyl)-4,7-diaza-spiro[2.6]nonane-5,8-dione → 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione (321918-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / sodium azide / dimethylsulfoxide / 5 h / 80 - 90 °C

2: 62 percent / 1 h / 180 - 230 °C / 0 Torr

With sodium azide; In dimethyl sulfoxide;

DOI:10.1021/ol0068187

Reference yield: 80.0%

1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione (321918-14-3) → 1,2,3,4,5,6-hexahydro-1-(4-methoxybenzyl)pyrrolo[3,2-e][1,4]diazepine-2,5-dione

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chloroform; at 40 ℃; for 20h;

DOI:10.1021/ol0068187

upstream raw materials:

2',3',4',5',6',7'-hexahydro-6'-imino-4'-(4-methoxybenzyl)spiro(cyclopropane-1,5'-[1H][1,4]-diazepine)-3',7'-dione

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