2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

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Chemical Name:2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide
CAS No.:1334673-85-6
Molecular Formula:C₂₇H₃₃N₅O₃
Molecular Weight:475.591
Hs Code.:

Synonyms:2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

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Chemical Property of 2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

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Technology Process of 2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

There total 12 articles about 2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1334675-19-2
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

: 1334673-85-6
2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

Guidance literature:: With 18-crown-6 ether; cesium fluoride; In acetonitrile; at 20 - 85 ℃;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1334673-85-6
2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran

2.2: pH 4

3.1: Jones reagent / water; acetone / 0.25 h

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

4.2: 0 - 20 °C

5.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

6.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

8.1: cesium fluoride; 18-crown-6 ether / acetonitrile / 20 - 85 °C

With sodium chlorite; potassium phosphate; potassium dihydrogenphosphate; Jones reagent; 18-crown-6 ether; aminosulfonic acid; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; sodium hydroxide; tricyclohexylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; mineral oil;

Reference yield:

: 1184926-29-1
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine

: 1334673-85-6
2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

Guidance literature:: Multi-step reaction with 5 steps

1: chloroform / 8 h / 20 °C / Reflux; Inert atmosphere

2: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

3: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

5: cesium fluoride; 18-crown-6 ether / acetonitrile / 20 - 85 °C

With sodium chlorite; potassium phosphate; potassium dihydrogenphosphate; 18-crown-6 ether; aminosulfonic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; tricyclohexylphosphine; palladium diacetate; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;