Technology Process of 2-decanoylamino-4-{3-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-phenylcarbamoyl}-butyric acid benzyl ester
There total 10 articles about 2-decanoylamino-4-{3-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-phenylcarbamoyl}-butyric acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-[(-3-t-butoxycarbonylamino-1-phenyl)-carbamoyl]-2-decanoyl-amino-butyric acid benzyl ester;
With
hydrogenchloride;
In
1,4-dioxane;
at 22 ℃;
for 4h;
2,5-diphenyloxazole-4-carboxylic acid;
With
triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
tetrahydrofuran;
at 0 - 22 ℃;
DOI:10.1016/S0968-0896(00)00069-9
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: chlorotrimethylsilane / 22 h / 22 °C
2.1: aq. Na2CO3 / dioxane / 0.08 h / 0 °C
2.2: 8.76 g / dioxane / 17 h / 22 °C
3.1: 5.70 g / KHCO3 / dimethylformamide / 14 h / 22 °C
4.1: 2.68 g / Zn; AcOH / tetrahydrofuran / 1 h / 22 °C
5.1: 3.69 g / Et3N / CH2Cl2 / 12 h / 22 °C
6.1: 557.2 mg / morpholine; Pd(PPh3)4 / tetrahydrofuran / 0.5 h / 22 °C
7.1: 194 mg / Et3N; diethylphosphoryl cyanide / tetrahydrofuran / 0 - 22 °C
8.1: HCl / dioxane / 4 h / 22 °C
8.2: 79 percent / Et3N; PyBroP / tetrahydrofuran / 0 - 22 °C
With
morpholine; hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); chloro-trimethyl-silane; diethylphosphoryl cyanide; sodium carbonate; potassium hydrogencarbonate; acetic acid; triethylamine; zinc;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
1.1: Esterification / 2.1: deprotonation / 2.2: Acylation / 3.1: Esterification / 4.1: deprotection / 5.1: Acylation / 6.1: deallylation / 7.1: Acylation / 8.1: deprotection / 8.2: Acylation;
DOI:10.1016/S0968-0896(00)00069-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 194 mg / Et3N; diethylphosphoryl cyanide / tetrahydrofuran / 0 - 22 °C
2.1: HCl / dioxane / 4 h / 22 °C
2.2: 79 percent / Et3N; PyBroP / tetrahydrofuran / 0 - 22 °C
With
hydrogenchloride; diethylphosphoryl cyanide; triethylamine;
In
tetrahydrofuran; 1,4-dioxane;
1.1: Acylation / 2.1: deprotection / 2.2: Acylation;
DOI:10.1016/S0968-0896(00)00069-9