acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester

Base Information

Chemical Name:acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester
CAS No.:1026940-82-8
Molecular Formula:C₂₂H₃₄O₅
Molecular Weight:378.509
Hs Code.:

acetic acid 2,6-di-<i>tert</i>-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester

Synonyms:acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester

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Chemical Property of acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester

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Technology Process of acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester

There total 5 articles about acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25637-16-5
4-bromotetrahydro-2H-pyran

: 157360-29-7
5-acetoxy-4,6-di-tert-butyl-2-hydroxybenzaldehyde

: 1026940-82-8
acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester

Guidance literature:: 4-bromotetrahydro-2H-pyran; With magnesium; In tetrahydrofuran;

5-acetoxy-4,6-di-tert-butyl-2-hydroxybenzaldehyde; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm030062a

Reference yield:

: 489-01-0
2,6-Di-t-butyl-4-methoxyphenol

: 1026940-82-8
acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / H₂SO₄ / 2 h / 70 °C

2.1: 80 percent / iodotrimethylsilane / CH₂Cl₂ / 48 h / 20 °C

3.1: AcOH; H₂SO₄ / 48 h / 20 °C

3.2: aq. HCl / ethanol / 2 h / Heating

4.1: 19.0 g / (CH₂)6N₄; aq. AcOH / 4 h / Heating

5.1: Mg / tetrahydrofuran

5.2: tetrahydrofuran / 2 h / 20 °C

With trimethylsilyl iodide; (CH₂)6N₄; sulfuric acid; magnesium; acetic acid; In tetrahydrofuran; dichloromethane; 5.2: Grignard reaction;
DOI:10.1021/jm030062a

Reference yield:

: 32102-41-3
4-acetoxy-3,5-di-tert-butylphenol

: 1026940-82-8
acetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: AcOH; H₂SO₄ / 48 h / 20 °C

1.2: aq. HCl / ethanol / 2 h / Heating

2.1: 19.0 g / (CH₂)6N₄; aq. AcOH / 4 h / Heating

3.1: Mg / tetrahydrofuran

3.2: tetrahydrofuran / 2 h / 20 °C

With (CH₂)6N₄; sulfuric acid; magnesium; acetic acid; In tetrahydrofuran; 3.2: Grignard reaction;
DOI:10.1021/jm030062a