1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide

Base Information

Chemical Name:1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide
CAS No.:752243-45-1
Molecular Formula:C₂₂H₃₆ClN₅O₅S
Molecular Weight:518.077
Hs Code.:

Synonyms:1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide

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Chemical Property of 1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide

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Technology Process of 1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide

There total 4 articles about 1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10314-98-4
1-benzyloxycarbonylpiperidine-4-carboxylic acid

: 752243-45-1
1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2 / toluene; dimethylformamide / 20 °C

2: CH₂Cl₂

3: H₂ / Pd/C / methanol

4: Et₃N / tetrahydrofuran

With oxalyl dichloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm049747g

Reference yield:

: 10314-99-5
benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate

: 752243-45-1
1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂

2: H₂ / Pd/C / methanol

3: Et₃N / tetrahydrofuran

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm049747g

Reference yield:

: 4-[bis-(3-dimethylamino-propyl)-carbamoyl]-piperidine-1-carboxylic acid benzyl ester

: 752243-45-1
1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid bis-(3-dimethylamino-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

2: Et₃N / tetrahydrofuran

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm049747g