(R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide

Base Information

• Chemical Name: (R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide
• CAS No.: 451503-24-5
• Molecular Formula: C₁₅H₁₉NO₂S
• Molecular Weight: 277.387
• Mol file: 451503-24-5.mol

Synonyms:(R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide

Chemical Property of (R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide

There total 2 articles about (R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyllithium (591-51-5) + (R)-(-)-N-[(1E)-3-furanylmethylene]-2-methyl-2-propanesulfinamide → (R)-N-[(R)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide (451503-25-6) + (R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide (451503-24-5)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 4h;

DOI:10.1016/S0957-4166(02)00099-X

Reference yield:

phenylmagnesium bromide + (R)-(-)-N-[(1E)-3-furanylmethylene]-2-methyl-2-propanesulfinamide → (R)-N-[(R)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide (451503-25-6) + (R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide (451503-24-5)

Guidance literature:

In toluene; at -45 ℃; for 4h; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(02)00099-X

Reference yield: 81.0%

(R)-N-[(S)-(3-furanyl)phenylmethyl]-2-methyl-2-propanesulfinamide (451503-24-5) → (α3S)-α-phenyl-3-furanmethanamine hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

DOI:10.1016/S0957-4166(02)00099-X

upstream raw materials:

phenyllithium