methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside

Base Information

Chemical Name:methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside
CAS No.:599178-12-8
Molecular Formula:C₂₇H₄₈O₉SSi₂
Molecular Weight:604.91
Hs Code.:

Synonyms:methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside

Suppliers and Price of methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside

There total 6 articles about methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 98-59-9
p-toluenesulfonyl chloride

: 599178-06-0
methyl 2-O-(2-hydroxyethyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranoside

: 599178-12-8
methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4039(03)01135-3

Reference yield:

: 532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,34436-17-4,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7
D-Ribose

: 599178-12-8
methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Dowex-50 (H+) / 4 °C

2: 61 percent / pyridine / 1 h / 20 °C

3: 71 percent / NaH / dimethylformamide / 8.5 h / -10 - 20 °C

4: 99 percent / LiBH₄ / methanol; tetrahydrofuran / 1.67 h / 0 °C

5: 92 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

With pyridine; dmap; lithium borohydride; Dowex-50 (H+); sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200600182

Reference yield:

: 76700-76-0
(6aR,8R,9R,9aS)-2,2,4,4-tetraisopropyl-8-methoxytetrahydro-6H-furo[3,2- f][1,3,5,2,4]trioxadisilocin-9-ol

: 599178-12-8
methyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2-O-(2-p-tolylsulfonyl)oxyethyl]-β-D-ribofuranoside

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / NaH / dimethylformamide / 8.5 h / -10 - 20 °C

2: 99 percent / LiBH₄ / methanol; tetrahydrofuran / 1.67 h / 0 °C

3: 92 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

With dmap; lithium borohydride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200600182