(S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile

Base Information

Chemical Name:(S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile
CAS No.:935871-98-0
Molecular Formula:C₂₇H₄₀BrNO₃Si
Molecular Weight:534.609
Hs Code.:

Synonyms:(S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile

Suppliers and Price of (S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile

There total 4 articles about (S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (S,1E,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienal oxime

: 935871-98-0
(S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile

Guidance literature:: With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jo062089i

Reference yield:

: (S,4E)-ethyl 2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienoate

: 935871-98-0
(S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: DIBAL / CH₂Cl₂; hexane / 0.5 h / 0 °C

2.1: MnO₂ / CH₂Cl₂ / 12 h / 20 °C

2.2: DMAP / CH₂Cl₂ / 24 h / 20 °C

3.1: 73 percent / NH₂OH*HCl / 1-methyl-pyrrolidin-2-one / 4 h / 50 °C

4.1: 92 percent / 1,1'-carbonyldiimidazole / CH₂Cl₂ / 12 h / 20 °C

With manganese(IV) oxide; hydroxylamine hydrochloride; diisobutylaluminium hydride; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; hexane; dichloromethane;
DOI:10.1021/jo062089i

Reference yield:

: (S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dien-1-ol

: 935871-98-0
(S,2Z,4E)-2-bromo-7-(tert-butyldimethylsilyloxy)-7-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}hepta-2,4-dienenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: MnO₂ / CH₂Cl₂ / 12 h / 20 °C

1.2: DMAP / CH₂Cl₂ / 24 h / 20 °C

2.1: 73 percent / NH₂OH*HCl / 1-methyl-pyrrolidin-2-one / 4 h / 50 °C

3.1: 92 percent / 1,1'-carbonyldiimidazole / CH₂Cl₂ / 12 h / 20 °C

With manganese(IV) oxide; hydroxylamine hydrochloride; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/jo062089i