3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester

Base Information

Chemical Name:3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester
CAS No.:341925-78-8
Molecular Formula:C₃₃H₅₅N₃O₆
Molecular Weight:589.816
Hs Code.:

Synonyms:3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester

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Chemical Property of 3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester

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Technology Process of 3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester

There total 5 articles about 3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 15761-38-3
L-N-Boc-Ala

: 791772-79-7
3-amino-5-(N-hexadecanoylamino)benzoic acid ethyl ester

: 341925-78-8
3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 21h;
DOI:10.1021/jo001079t

Reference yield:

: 535-87-5
3.5-diaminobenzoic acid

: 341925-78-8
3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / SOCl₂ / 24 h / Heating

2: 83 percent / Et₃N / H₂O; dioxane / 11 h / 0 - 20 °C

3: 93 percent / Et₃N; dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / CHCl₃ / 21 h / 0 - 20 °C

4: 99 percent / HCl / dioxane / 3 h / 20 °C

5: 60 percent / 1-hydroxybenzotriazole; Et₃N; dicyclohexylcarbodiimide / dimethylformamide / 21 h / 0 - 20 °C

With hydrogenchloride; thionyl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001079t

Reference yield:

: 1949-51-5
3,5-diaminobenzoic acid ethyl ester

: 341925-78-8
3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-palmitoylamino)benzoicacid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / Et₃N / H₂O; dioxane / 11 h / 0 - 20 °C

2: 93 percent / Et₃N; dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / CHCl₃ / 21 h / 0 - 20 °C

3: 99 percent / HCl / dioxane / 3 h / 20 °C

4: 60 percent / 1-hydroxybenzotriazole; Et₃N; dicyclohexylcarbodiimide / dimethylformamide / 21 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001079t