(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester

Base Information

Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester
CAS No.:82010-40-0
Molecular Formula:C₂₁H₂₇F₃O₅
Molecular Weight:416.438
Hs Code.:

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester

There total 9 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1756-18-9
(2RS)-2,3-dihydroxy-3-methylbutanoic acid

: 82010-40-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: HCl(g) / 16 h / Ambient temperature

2: 4-toluenesulfonic acid / benzene / Heating

3: 82 percent / LiAlH₄ / diethyl ether / 3 h

4: pyridine / 5 h / Ambient temperature

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In diethyl ether; benzene;
DOI:10.1021/jo00138a018

Reference yield:

: 80567-47-1
methyl-(+/-)-2,3-dihydroxy-3-methylbutyrate

: 82010-40-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 4-toluenesulfonic acid / benzene / Heating

2: 82 percent / LiAlH₄ / diethyl ether / 3 h

3: pyridine / 5 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In diethyl ether; benzene;
DOI:10.1021/jo00138a018

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 82010-40-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / 4-toluenesulfonic acid / benzene / Heating

2: 1.) ozone, 2) (C₆H₅)3P / 1.) CH₂Cl₂, from -20 deg C to 20 deg C, 2.) room temp., 1 h

3: NaOBr / dioxane; H₂O / 3 h / 0 °C

4: LiAlH₄ / diethyl ether / 2 h / Heating

5: pyridine / 5 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; sodium hypobromide; toluene-4-sulfonic acid; ozone; triphenylphosphine; In 1,4-dioxane; diethyl ether; water; benzene;
DOI:10.1021/jo00138a018