2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile

Base Information

Chemical Name:2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile
CAS No.:1198212-02-0
Molecular Formula:C₂₆H₂₀FN₅O₃S₂
Molecular Weight:533.607
Hs Code.:

Synonyms:2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile

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Chemical Property of 2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile

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Technology Process of 2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile

There total 5 articles about 2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1030620-02-0
4-(chloromethyl)-N-(4-fluorophenyl)-1,3-thiazole-2-amine

: 1198212-16-6
4-[4-(2-hydroxyethoxy)phenyl]-2-methoxy-6-sulphanylpyridine-3,5-dicarbonitrile

: 1198212-02-0
2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile

Guidance literature:: 4-(chloromethyl)-N-(4-fluorophenyl)-1,3-thiazole-2-amine; 4-[4-(2-hydroxyethoxy)phenyl]-2-methoxy-6-sulphanylpyridine-3,5-dicarbonitrile; With sodium tetrahydroborate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; at 50 ℃;

With acetic acid; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 459-05-2
(4-fluoro-phenyl)-thiourea

: 1198212-02-0
2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 4 h / 80 °C

2: potassium carbonate; sodium tetrahydroborate / N,N-dimethyl-formamide; ethanol; water / 50 °C

With sodium tetrahydroborate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1198212-14-4
2-amino-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile

: 1198212-02-0
2-[({2-[(4-Fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)sulphanyl]-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper dichloride; isopentyl nitrite / acetonitrile / 20 °C

2.1: sodium sulfide / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 20 - 50 °C

3.1: potassium carbonate; sodium tetrahydroborate / N,N-dimethyl-formamide; ethanol; water / 50 °C

With sodium sulfide; sodium tetrahydroborate; potassium carbonate; copper dichloride; isopentyl nitrite; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;