2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine

Base Information

Chemical Name:2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine
CAS No.:1027340-37-9
Molecular Formula:C₁₈H₁₈N₂O₂
Molecular Weight:294.353
Hs Code.:

Synonyms:2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine

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Chemical Property of 2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine

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Technology Process of 2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine

There total 4 articles about 2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1027340-27-7
2-ethynyl-5-methoxyaniline

: 1027340-37-9
2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine

Guidance literature:: With Au₂(BIPHEP)(NTf₂)₂; In 1,2-dichloro-ethane; at 25 ℃; for 6h; Inert atmosphere;
DOI:10.1055/s-0035-1561305

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 1027340-37-9
2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine

Guidance literature:: Multi-step reaction with 4 steps

1: [bis(pyridine)iodine]⁺ tetrafluoroborate; tetrafluoroboric acid / dichloromethane / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 6 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: Au₂(BIPHEP)(NTf₂)₂ / 1,2-dichloro-ethane / 6 h / 25 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrafluoroboric acid; Au₂(BIPHEP)(NTf₂)₂; tetrabutyl ammonium fluoride; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: |Barluenga Lodination / 2: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0035-1561305

Reference yield:

: 1027340-49-3
5-methoxy-2-((trimethylsilyl)ethynyl)aniline

: 1027340-37-9
2-(7-methoxy-4-methyl-2-quinolinyl)-5-methoxyphenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2: Au₂(BIPHEP)(NTf₂)₂ / 1,2-dichloro-ethane / 6 h / 25 °C / Inert atmosphere

With Au₂(BIPHEP)(NTf₂)₂; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1055/s-0035-1561305