N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea

Base Information

Chemical Name:N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea
CAS No.:1356835-72-7
Molecular Formula:C₂₄H₂₁BrN₄O₄
Molecular Weight:509.359
Hs Code.:

Synonyms:N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea

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Chemical Property of N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea

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Technology Process of N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea

There total 4 articles about N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-2-methylaniline

: 23138-55-8
3-Bromophenyl isocyanate

: 1356835-72-7
N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 16h;
DOI:10.1021/jm2013453

Reference yield:

: 26759-46-6
methyl 2-amino-4,5-dimethoxybenzoate

: 1356835-72-7
N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / methanol; N,N-dimethyl-formamide / 16 h / Reflux

2: trichlorophosphate / 2 h / Reflux

3: tetrabutylammomium bromide; sodium hydroxide / butanone / 0.5 h / Reflux

4: triethylamine / chloroform / 16 h / 20 °C

With tetrabutylammomium bromide; sodium methylate; triethylamine; sodium hydroxide; trichlorophosphate; In methanol; chloroform; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm2013453

Reference yield:

: 13794-72-4
3H-6,7-dimethoxyquinazolin-4-one

: 1356835-72-7
N-(3-bromophenyl)-N'-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]-2-methylphenyl}urea

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 2 h / Reflux

2: tetrabutylammomium bromide; sodium hydroxide / butanone / 0.5 h / Reflux

3: triethylamine / chloroform / 16 h / 20 °C

With tetrabutylammomium bromide; triethylamine; sodium hydroxide; trichlorophosphate; In chloroform; butanone;
DOI:10.1021/jm2013453