Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

Base Information

Chemical Name:Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester
CAS No.:98293-12-0
Molecular Formula:C₅₀H₄₄Cl₃N₆O₁₀P
Molecular Weight:1026.27
Hs Code.:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

Synonyms:Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

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Chemical Property of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

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Technology Process of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

There total 3 articles about Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 68892-41-1
5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

: 93636-01-2
2,6-dichlorophenyl 5-chloro-8-quinolyl phosphorochloridate

: 98293-12-0
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; for 0.75h;
DOI:10.1246/cl.1985.347

Reference yield:

: 130-16-5
5-Chloro-8-hydroxyquinoline

: 98293-12-0
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / -10 deg C to room temp.

2: 81 percent / 1-methylimidazole / tetrahydrofuran / 0.75 h

With 1-methyl-1H-imidazole; triethylamine; In tetrahydrofuran;
DOI:10.1246/cl.1985.347

Reference yield:

: 53676-19-0
2,6-dichlorophenyl phosphorodichloridate

: 98293-12-0
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / -10 deg C to room temp.

2: 81 percent / 1-methylimidazole / tetrahydrofuran / 0.75 h

With 1-methyl-1H-imidazole; triethylamine; In tetrahydrofuran;
DOI:10.1246/cl.1985.347