Technology Process of 4-methyl-11,11-diphenyl-10,11-dihydro-5H-dibenzo[b,f]azepine
There total 12 articles about 4-methyl-11,11-diphenyl-10,11-dihydro-5H-dibenzo[b,f]azepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
aluminum (III) chloride;
In
dichloromethane;
for 20h;
Reagent/catalyst;
Temperature;
Solvent;
Reflux;
DOI:10.1071/CH12548
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sulfuric acid / 8 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2.5 h / 20 °C / Cooling with ice
3: thionyl chloride; pyridine / 3.5 h / 5 °C / Heating
4: ethanol; water / 5 h / Reflux
5: sulfuric acid / 12 h / Reflux
6: pyridine / chloroform / 4 h / 20 - 80 °C
7: tetrahydrofuran; diethyl ether / 11 h / 20 °C
8: aluminum (III) chloride / dichloromethane / 20 h / Reflux
With
pyridine; aluminum (III) chloride; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; water;
8: |Friedel-Crafts Alkylation;
DOI:10.1071/CH12548
- Guidance literature:
-
Multi-step reaction with 7 steps
1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2.5 h / 20 °C / Cooling with ice
2: thionyl chloride; pyridine / 3.5 h / 5 °C / Heating
3: ethanol; water / 5 h / Reflux
4: sulfuric acid / 12 h / Reflux
5: pyridine / chloroform / 4 h / 20 - 80 °C
6: tetrahydrofuran; diethyl ether / 11 h / 20 °C
7: aluminum (III) chloride / dichloromethane / 20 h / Reflux
With
pyridine; aluminum (III) chloride; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; water;
7: |Friedel-Crafts Alkylation;
DOI:10.1071/CH12548
