(S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide

Base Information

Chemical Name:(S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide
CAS No.:1262439-63-3
Molecular Formula:C₂₀H₂₁N₃O₃
Molecular Weight:351.405
Hs Code.:

Synonyms:(S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide

Chemical Property:

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Technology Process of (S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide

There total 7 articles about (S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1262439-62-2
tert-butyl (S)-1-((3-(4-methoxyphenyl)isoxazol-5-yl)methylcarbamoyl)-2-phenylethylcarbamate

: 1262439-63-3
(S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide

Guidance literature:: With trifluoroacetic acid; In water; for 0.166667h;
DOI:10.1021/jm1008715

Reference yield:

: 1262439-59-7
5-(azidomethyl)-3-(4-methoxyphenyl)isoxazole

: 1262439-63-3
(S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

3: trifluoroacetic acid / water / 0.17 h

With triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 1: Staudinger reaction / 1: Staudinger reaction;
DOI:10.1021/jm1008715

Reference yield:

: 1308264-80-3
(3-(4-methoxyphenyl)isoxazol-5-yl)methyl 4-methylbenzenesulfonate

: 1262439-63-3
(S)-2-amino-N-((3-(4-methoxyphenyl)isoxazol-5-yl)methyl)-3-phenylpropaneamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 20 °C / Inert atmosphere

4: trifluoroacetic acid / water / 0.17 h

With sodium azide; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2: Staudinger reaction / 2: Staudinger reaction;
DOI:10.1021/jm1008715