N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine

Base Information

Chemical Name:N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine
CAS No.:158094-55-4
Molecular Formula:C₃₁H₃₉N₅O₂
Molecular Weight:513.683
Hs Code.:

Synonyms:N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine

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Chemical Property of N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine

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Technology Process of N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine

There total 8 articles about N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 28797-48-0
11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

: 158094-54-3
N,N-diethyl-N'-benzyl-1,6-hexanediamine

: 158094-55-4
N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine

Guidance literature:: In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1021/jm00046a021

Reference yield:

: 1947-00-8
6-(benzyloxycarbonylamino)hexanoic acid

: 158094-55-4
N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dioxane / 0.5 h / 5 °C

2: dioxane / 18 h

3: hydrogen / 10percent Pd/C / ethanol / 1 h / 1551.4 Torr / Ambient temperature

4: 10 M BH₃*MeSMe / bis-(2-methoxy-ethyl) ether / 14 h / 120 °C

5: benzene / 7 h / Heating

6: NaBH₄ / ethanol / 3 h / Ambient temperature

7: 86 percent / dimethylformamide / 72 h / Ambient temperature

With sodium tetrahydroborate; dimethylsulfide borane complex; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00046a021

Reference yield:

: C₁₇H₂₃NO₆

: 158094-55-4
N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine

Guidance literature:: Multi-step reaction with 6 steps

1: dioxane / 18 h

2: hydrogen / 10percent Pd/C / ethanol / 1 h / 1551.4 Torr / Ambient temperature

3: 10 M BH₃*MeSMe / bis-(2-methoxy-ethyl) ether / 14 h / 120 °C

4: benzene / 7 h / Heating

5: NaBH₄ / ethanol / 3 h / Ambient temperature

6: 86 percent / dimethylformamide / 72 h / Ambient temperature

With sodium tetrahydroborate; dimethylsulfide borane complex; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00046a021