(E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

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Chemical Name:(E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid
CAS No.:1348742-53-9
Molecular Formula:C₁₅H₁₁ClF₃N₃O₄
Molecular Weight:389.718
Hs Code.:

Synonyms:(E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

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Chemical Property of (E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

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Technology Process of (E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

There total 2 articles about (E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: sodium (E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylate

: 1348742-53-9
(E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

Guidance literature:: With hydrogenchloride; In water;
DOI:10.1016/j.tet.2014.09.093

Reference yield:

: 1037590-08-1
ethyl 4-(4-chlorophenyl)-2-oxo-6-(trifluoromethyl)-2H-pyran-3-carboxylate

: 1348742-53-9
(E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

: (Z)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

Guidance literature:: ethyl 4-(4-chlorophenyl)-2-oxo-6-(trifluoromethyl)-2H-pyran-3-carboxylate; With sodium azide; In ethanol; for 4.5h; Reflux;

With hydrogenchloride; In ethanol; water; Solvent; Temperature; Time; Overall yield = 79 %; diastereoselective reaction;
DOI:10.1016/j.tet.2014.09.093

Reference yield: 97.0%

: 1348742-53-9
(E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

: (4-chlorophenyl)(5-trifluoromethyl-1,2,3-triazol-4-yl)methylenemalonic acid

Guidance literature:: (E)-3-(4-chlorophenyl)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid; With sodium hydroxide; In water; at 20 ℃;

With hydrogenchloride; In water;
DOI:10.1016/j.tet.2014.09.093