tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate

Base Information

• Chemical Name: tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate
• CAS No.: 1332525-42-4
• Molecular Formula: C₂₃H₃₀N₄O₆
• Molecular Weight: 458.514

Synonyms:tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate

Chemical Property of tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate

Chemical Property:

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Technology Process of tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate

There total 5 articles about tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(2-morpholinopyrimidin-4yloxy)-1H-benzo[d]-[1,2,3] triazole (1332525-41-3) + (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) → tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate (1332525-42-4)

Guidance literature:

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester; With potassium carbonate; In acetonitrile; at 20 ℃; for 0.25h;

1-(2-morpholinopyrimidin-4yloxy)-1H-benzo[d]-[1,2,3] triazole; In acetonitrile; at 50 ℃; for 24h;

DOI:10.1039/c1ob05313b

Reference yield: 29.0%

2-morpholinopyrimidin-4(3H)-one + (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) + (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (56602-33-6) → 1-(2-morpholinopyrimidin-4yloxy)-1H-benzo[d]-[1,2,3] triazole (1332525-41-3) + tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate (1332525-42-4)

Guidance literature:

2-morpholinopyrimidin-4(3H)-one; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.25h;

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester; In acetonitrile; at 60 ℃; for 72h;

DOI:10.1039/c1ob05313b

Reference yield: 6.0%

morpholine (110-91-8,99108-56-2) + tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-(benzylsulfonyl)pyrimidin-4-yloxy)phenyl)ethylcarbamate (1332525-31-1) → C15H17N3O3S (1332525-32-2) + tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-morpholinopyrimidin-N-yloxy) phenyl) ethylcarbamate (1332525-42-4) + 4,4′-(pyrimidine-2,4-diyl)dimorpholine

Guidance literature:

In 1,4-dioxane; at 60 ℃; for 12h;

DOI:10.1039/c1ob05313b

upstream raw materials:

morpholine

tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-(benzylsulfonyl)pyrimidin-4-yloxy)phenyl)ethylcarbamate

tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(2-(benzylsulfanyl)pyrimidin-4-yloxy)phenyl)ethylcarbamate

1-(2-morpholinopyrimidin-4yloxy)-1H-benzo[d]-[1,2,3] triazole

Downstream raw materials:

(S)-Nα-Fmoc-3-(4-(4-(2-morpholinopyrimidin-N-yloxy)phenyl)-2-amino)propanoic acid

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