N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide
CAS No.:1195778-53-0
Molecular Formula:C₂₆H₂₃N₅O₃S
Molecular Weight:485.566
Hs Code.:

Synonyms:N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

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Chemical Property of N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

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Technology Process of N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

There total 10 articles about N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1195781-14-6
N-[6-(4-aminophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

: 29313-32-4
2-phenylacetyl isothiocyanate

: 1195778-53-0
N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: In ethanol; toluene; at 20 ℃; for 1h;

Reference yield:

: 1195781-05-5
benzyl {4-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

: 1195778-53-0
N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; iron; calcium chloride / ethanol / 16 h / Reflux

2.1: pyridine / 16 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: trifluoroacetic anhydride / tetrahydrofuran / 48 h / 20 °C

4.3: 10 h / 45 °C

5.1: ISOPROPYLAMIDE / 1 h / 20 °C

6.1: water; barium(II) hydroxide / 1,2-dimethoxyethane / 36 h / 90 °C

7.1: ethanol; toluene / 1 h / 20 °C

With pyridine; water; iron; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; calcium chloride; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1195781-07-7
benzyl {4-[(6-aminopyridin-3-yl)oxy]phenyl}carbamate

: 1195778-53-0
N-[6-(4-{[(phenylacetyl)carbamothioyl]amino}phenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: trifluoroacetic anhydride / tetrahydrofuran / 48 h / 20 °C

3.3: 10 h / 45 °C

4.1: ISOPROPYLAMIDE / 1 h / 20 °C

5.1: water; barium(II) hydroxide / 1,2-dimethoxyethane / 36 h / 90 °C

6.1: ethanol; toluene / 1 h / 20 °C

With pyridine; water; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; toluene;