1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene

Base Information

Chemical Name:1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene
CAS No.:1332523-75-7
Molecular Formula:C₁₂H₁₃F₃INO₃
Molecular Weight:403.14
Hs Code.:

Synonyms:1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene

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Chemical Property of 1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene

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Technology Process of 1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene

There total 1 articles about 1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 73903-22-7
N-<2-(3,5-Dimethoxyphenyl)athyl>-trifluoracetamid

: 1332523-75-7
1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene

Guidance literature:: With iodine; silver sulfate; In ethanol; at 0 ℃; for 6.5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.125

Reference yield: 83.0%

: 1332523-75-7
1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene

: 107-19-7
propargyl alcohol

: 1332523-76-8
3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-ynol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.125

Reference yield:

: 1332523-75-7
1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene

: 1332523-71-3
ethenyl (Z)-3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-enyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 48 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; hydrogen; nickel diacetate; ethylenediamine / ethanol / 16 h / 20 °C / 760.05 Torr

3: pyridine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; hydrogen; nickel diacetate; ethylenediamine; diethylamine; In ethanol; dichloromethane; 1: Sonogashira coupling;
DOI:10.1016/j.tet.2011.05.125