cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate

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Chemical Name:cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate
CAS No.:1018674-43-5
Molecular Formula:C₃₇H₅₃N₃O₅
Molecular Weight:619.845
Hs Code.:

Synonyms:cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate

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Chemical Property of cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate

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Technology Process of cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate

There total 10 articles about cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1018674-39-9
(2E)-3-(3-formylphenyl)-N-[1-(2-methylpropoxy)ethoxy]prop-2-enamide

: cyclopentyl (2S)-{[4-(aminomethyl)benzyl]amino}(cyclohexyl)acetate hydrochloride

: 1018674-43-5
cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate

Guidance literature:: (2E)-3-(3-formylphenyl)-N-[1-(2-methylpropoxy)ethoxy]prop-2-enamide; cyclopentyl (2S)-{[4-(aminomethyl)benzyl]amino}(cyclohexyl)acetate hydrochloride; In 1,2-dichloro-ethane; for 17h;

With sodium cyanoborohydride; In 1,2-dichloro-ethane; for 2h;

Reference yield:

: (2E)-3-[3-(hydroxymethyl)phenyl]-prop-2-enoic acid

: 1018674-43-5
cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C

1.2: 2.5 h / 20 °C

2.1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C

3.1: 1,2-dichloro-ethane / 17 h

3.2: 2 h

With manganese(IV) oxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 1018674-43-5
cyclopentyl (2S)-cyclohexyl[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}benzyl)amino]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 16 h / 20 °C / pH 6

1.2: pH 3

2.1: lithium aluminium tetrahydride / tetrahydrofuran; 1,4-dioxane / 16 h / 0 - 20 °C

2.2: 0.5 h / 0 °C

3.1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

6.1: 1,2-dichloro-ethane / 17 h

6.2: 2 h

With hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane;