(7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione

Base Information

• Chemical Name: (7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione
• CAS No.: 1229041-63-7
• Molecular Formula: C₃₀H₃₈O₃Si
• Molecular Weight: 474.715
• Mol file: 1229041-63-7.mol

Synonyms:(7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione

Chemical Property of (7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione

There total 30 articles about (7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C30H40O2Si → (7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione (1229041-63-7)

Guidance literature:

C₃₀H₄₀O₂Si; With tert.-butylhydroperoxide; selenium(IV) oxide; In decane; dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

With sodium hydrogencarbonate; Dess-Martin periodane; In decane; dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.152329

Reference yield:

C36H44O4Si → (7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione (1229041-63-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 23 ℃;

DOI:10.1021/ja103666n

Reference yield:

C29H36O4Si → (7aS)-3a-(3-(tert-butyldiphenylsilyloxy)propyl)-6-methyl-3-methylenetetrahydro-1H-indene-2,4(5H,6H)-dione (1229041-63-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 ℃; Inert atmosphere;

DOI:10.1021/jo300872y

upstream raw materials:

(3aS,5R,6R,6aR)-6-iodo-5-methylhexahydro-2H-cyclopenta[b]furan-2-one

(2S,4R)-4-methyl-2-(2-(triethylsilyloxy)ethyl)cyclopentanone

(1S,2S,4R)-4-methyl-2-(2-(triethylsilyloxy)ethyl)cyclopentanol

(1S,2S,4R)-1-((E)-6-(tert-butyldiphenylsilyloxy)-1-phenoxyhex-2-en-3-yl)-4-methyl-2-(2-(triethylsilyloxy)ethyl)cyclopentanol

Downstream raw materials:

(+)-fawcettimine