(2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde

Base Information

Chemical Name:(2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde
CAS No.:119243-81-1
Molecular Formula:C₂₂H₃₄O₆
Molecular Weight:394.508
Hs Code.:

Synonyms:(2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde

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Chemical Property of (2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde

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Technology Process of (2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde

There total 6 articles about (2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119243-80-0
{(2R,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxiranyl}-methanol

: 119243-81-1
(2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 0 ℃;
DOI:10.1021/ja00187a081

Reference yield:

: (4-Benzyloxy)butylmagnesium bromide

: 119243-81-1
(2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DMS*CuBr, TMEDA / 1.) Et₂O, -78 deg C, 2.) -78 deg C

2: 98 percent / DIBAL / CH₂Cl₂ / -78 °C

3: Ti(O-iPr)4, D-DIPT, t-BuOOH, 4-Angstroem sieves / CH₂Cl₂ / -50 °C

4: ClCOCOCl, DMSO, Et₃N / CH₂Cl₂ / -78 - 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; oxalyl dichloride; copper(I) bromide dimethylsulfide complex; N,N,N,N,-tetramethylethylenediamine; 4 A molecular sieve; diisobutylaluminium hydride; D-(-)-diisopropyl tartrate; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1021/ja00187a081

Reference yield:

: 119243-76-4
(R)-5-(2-Methoxy-ethoxymethoxy)-4-methyl-pent-1-yne

: 119243-81-1
(2S,3S)-3-(4-Benzyloxy-butyl)-3-[(R)-3-(2-methoxy-ethoxymethoxy)-2-methyl-propyl]-oxirane-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, -78 -> 78 deg C, 2.) -78 deg C

2: 1.) DMS*CuBr, TMEDA / 1.) Et₂O, -78 deg C, 2.) -78 deg C

3: 98 percent / DIBAL / CH₂Cl₂ / -78 °C

4: Ti(O-iPr)4, D-DIPT, t-BuOOH, 4-Angstroem sieves / CH₂Cl₂ / -50 °C

5: ClCOCOCl, DMSO, Et₃N / CH₂Cl₂ / -78 - 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; oxalyl dichloride; copper(I) bromide dimethylsulfide complex; N,N,N,N,-tetramethylethylenediamine; 4 A molecular sieve; diisobutylaluminium hydride; D-(-)-diisopropyl tartrate; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1021/ja00187a081